2-(2-hydroxyphenyl)benzimidazoles useful for treating...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S310700

Reexamination Certificate

active

07915299

ABSTRACT:
The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.

REFERENCES:
patent: 3251837 (1966-05-01), Holland
patent: 3269955 (1966-08-01), Rodgers et al.
patent: 3526627 (1970-09-01), Brooks
patent: 5240962 (1993-08-01), Nakatsu et al.
patent: 2006/0128790 (2006-06-01), Chu et al.
patent: 2006/0135713 (2006-06-01), Leclerc et al.
patent: 60-25984 (1985-02-01), None
patent: 2004-067629 (2004-03-01), None
patent: 98/12185 (1998-03-01), None
patent: WO 2004/041256 (2004-05-01), None
patent: WO 2004/065370 (2004-08-01), None
patent: 2004/101505 (2004-11-01), None
patent: 2005/051894 (2005-06-01), None
patent: 2005/051984 (2005-06-01), None
patent: WO 2005/105785 (2005-11-01), None
patent: 2008/059023 (2008-05-01), None
patent: 2008/059024 (2008-05-01), None
patent: 2008/059025 (2008-05-01), None
Saloutin et al. Journal of Fluorine Chemistry 1999, 94, 83-90.
Giron, D. J. Therm. Anal. Cal. 2001, 64, pp. 37-60.
Giron, D. J. Therm. Anal. Cal. 2002, 68, pp. 335-357.
B. Rodriquez-Spong et al. Advanced Drug Delivery Reviews, 2004, 56, pp. 241-274.
Souillac, et al., Characterization of Delivery Systems, Differential Scanning Calorimetry, pp. 217-218 (in Encyclopedia of Controlled Drug Delivery, 1999, John Wiley & Sons, pp. 212-227).
PCT/EP2007/062409, International Preliminary Report on Patentability and Written Opinion mailed May 28,2009.
PCT/EP2007/062409, International Search Report mailed May 3, 2008.
Silverman, The Organic Chemistry of Drug Design and Drug Action, 2d ed. (2004) Elsevier, pp. 29-32.
Office Action for U.S. Appl. No. 12/515,045, dated Dec. 27, 2010.
Terada et al., “Structural Requirements of Salicylanilides for Uncoupling Activity in Mitochondria: Quantitative Analysis of Structure-Uncoupling Relationships” Biochim. Biophys. Acta, vol. 936(3), pp. 504-512 (1988).
Miyoshi et al., “Quantitative Relationship between Protonophoric and Uncoupling Activities of Analogs of SF6847 (2,6-di-t-butyl-4-(2′,2′-dicyanovinyl)phenol)” Biochim. Biophys. Acta, vol. 891, pp. 293-299 (1987).
De Gray et al., “Three Detailed Hypotheses Implicating Oxidative Damage to Mitochondria as a Major Driving Force in Homeotherm Aging” Eur. J. Biochem., vol. 269, p. 1995 (2002).
El Din, “Synthesis of Some New Thiadiazine-1,1-Dioxide Derivatives” Delta J. Sci., vol. 19(2), pp. 115-126 (1995).
Pending claims for U.S. Appl. No. 12/515,045, dated Nov. 16, 2010.
Pending claims for U.S. Appl. No. 12/515,051, dated Nov. 16, 2010.
Pending claims for U.S. Appl. No. 12/515,056, dated Nov. 16, 2010.
Guillory, “Generation of Polymorphs, Hydrates, Solvates, and Amorphous Solids” in Polymorphism in Pharmaceutical Solids, pp. 183-226 (H.G. Brittain, ed., 1999).
Byrn et al., Solid-State Chemistry of Drugs, pp. 233-248 (2nd ed., 1999).

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