2,2-Difluoro-trans-4,5,13,14-tetrahydro-PGI.sub.1 compounds

Details 2,2-Difluoro-trans-4,5,13,14-tetrahydro-PGI.sub.1 compounds 2,2-Difluoro-trans-4,5,13,14-tetrahydro-PGI.sub.1 compounds

1978-06-14

1980-07-08

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26034622, 542426, C07D30793

Patent

active

042117143

ABSTRACT:
The present invention relates to certain structural and pharmacological analogs of prostacyclin (PGI.sub.2) which are 2,2-difluoro-trans-4,5,13,14-tetradehydro-PGI.sub.1 compounds. These novel pharmacological agents are useful as smooth muscle stimulators.

REFERENCES:
Fried et al., Proc. Natl. Acad. Sci. 74, 2199, 1977.

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