Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1975-02-24
1977-01-04
Killos, Paul J.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260468D, 260514D, 260520B, C07C 6522, C07C 6176
Patent
active
040013006
ABSTRACT:
2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.
REFERENCES:
patent: 3775462 (1973-11-01), Axen
Armitage Robert A.
Killos Paul J.
The Upjohn Company
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