2,2-Difluoro-13,14-dihydro-PGA.sub.1 analogs

Details 2,2-Difluoro-13,14-dihydro-PGA.sub.1 analogs 2,2-Difluoro-13,14-dihydro-PGA.sub.1 analogs

1976-09-17

1977-12-27

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260404, 260408, 260514D, C07C17700

Patent

active

040656330

ABSTRACT:
2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.

REFERENCES:
patent: 3847967 (1974-12-01), Lincoln et al.
patent: 3919286 (1975-12-01), Bundy et al.
patent: 3962293 (1976-06-01), Magerlin
Burger, Medicinal Chemistry, pp. 81, 82 (1960).

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