2,2-Difluoro-13,14-didehydro-PGE.sub.1 compounds

Details 2,2-Difluoro-13,14-didehydro-PGE.sub.1 compounds 2,2-Difluoro-13,14-didehydro-PGE.sub.1 compounds

1977-03-07

1979-04-24

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560121, 562503, C07C17700

Patent

active

041511840

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. A so provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3914282 (1975-10-01), Pike
patent: 3931411 (1976-01-01), Potts
patent: 3932463 (1976-01-01), Schaub et al.
patent: 3933889 (1976-01-01), Maserlin
patent: 3933899 (1976-01-01), Nelson
patent: 3959346 (1976-05-01), Schneider
patent: 3962293 (1976-06-01), Magerlin
Pappo et al., Tet. Letters, 2627 (1972).
Burger, Medicinal Chemistry, pp. 81, 82 (1960).

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