2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyr

Details 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyr 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyr

1995-06-06

1996-11-12

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514318, 514337, 514218, 514339, 514309, 546256, 546194, 5462784, 546141, 546257, 5462771, 546 13, 5462827, 5462831, 540524, A61K 3144, C07D40714

Patent

active

055740499

ABSTRACT:
2,2-di(C.sub.1-5 alkyl)- and trans-2,2-di(C.sub.1-5 alkyl)-3,4-dihydro-3-hydroxy-6-(pyridin-4-yl)-2H-1-benzopyrans, e.g. of formula ##STR1## in which R.sub.1 and R.sub.2 =H, alkyl, hydroxyalkyl or alkoxyalkyl, at least one being other than H, R.sub.3 =typically a 2-piperidinone group, R.sub.4 =H and R.sub.5 =--OH or R.sub.4 +R.sub.5 =an additional bond, and R.sub.6, R.sub.7 are alkyl and R.sub.8 is H or alkyl, and N-oxides, esters and salts thereof, processes for their production and their uses as pharmaceuticals e.g. as K.sup.+ -channel openers, bronchodilators and asthma prophylactic agents.

REFERENCES:
J. Med. Chem., vol. 33, No. 2, pp. 492-504 (1990).

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