2,2-di-substituted benzopyran leukotriene-D.sub.4 antagonists

Details 2,2-di-substituted benzopyran leukotriene-D.sub.4 antagonists 2,2-di-substituted benzopyran leukotriene-D.sub.4 antagonists

1988-05-20

1990-08-21

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549401, A61K 3135, C07D31122

Patent

active

049506846

ABSTRACT:
This invention relates to novel compounds having a 2,2-di-substituted chromanonyl (benzopyran) ring structure which are antagonists of leukotriene D.sub.4 (LTD.sub.4) and the slow reacting substance of anaphylaxis (SRS-A). The compounds of this invention are useful as pharmaceutical agents to prevent or alleviate the symptoms associated with LTD.sub.4, such as allergic reactions and inflammatory conditions.

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