2,2-di-substituted benzopyran leukotriene-D.sub.4 antagonists

Details 2,2-di-substituted benzopyran leukotriene-D.sub.4 antagonists 2,2-di-substituted benzopyran leukotriene-D.sub.4 antagonists

1990-06-04

1992-03-03

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514320, 546196, 548525, A61K 3140, A61K 31435, C07D40512

Patent

active

050933531

ABSTRACT:
This invention relates to 2,2-di-substituted benzopyran compounds which possess leukotriene-D.sub.4 (LTD.sub.4) antagonistic activity. In particular this invention relates to LTD.sub.4 antagonists of the formula: ##STR1## or a pharmaceutically acceptable addition salt thereof, wherein R.sup.1 is methyl, phenyl, ##STR2## wherein X.sub.1 and X.sub.2 may be the same or different and are members of the group comprising hydrogen, --Cl, --Br, --CF.sub.3, --NH.sub.2, --NO.sub.2, or straight or branched chain alkyl of 1-3 carbon atoms;

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