2,2'-bi-1H-imidazoles

Details 2,2'-bi-1H-imidazoles 2,2'-bi-1H-imidazoles

1990-10-17

1992-09-15

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

548336, 546278, 514341, 514397, A61K 31695, A61K 3144, A61K 31415, C07D40300

Patent

active

051478633

ABSTRACT:
This invention relates to novel derivatives of 2,2'-bi-1H-imidazoles, to the processes and intermediates used in their preparation, to their ability to exert the pharmacologic effects of lowering high blood pressure and of increasing heart contractile force and to their use as chemotherpauetic agents useful in treating cardiac insufficiency and hypertension.

REFERENCES:
patent: 2155555 (1939-04-01), Karrer
patent: 4347364 (1982-08-01), Walser et al.
patent: 4466976 (1984-08-01), Klose et al.
Chem. Abs., vol. 80, 80:82801a (1974).
K. Lehmstedt et al., Chemische Berichte, 76(B), 879-891 (1943).
P. Melloni et al., J. Med. Chem., 15(9), 926-930 (1972).
P. Rasmussen et al., J. Am. Chem. Soc., 104, 6155-156 (1982).
Chemical Abstracts 93:187324u (1980).

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