2-(2-Amino-4-thiazolyl)-2-methoxyimino-acetic acid derivatives

Details 2-(2-Amino-4-thiazolyl)-2-methoxyimino-acetic acid derivatives 2-(2-Amino-4-thiazolyl)-2-methoxyimino-acetic acid derivatives

1981-05-04

1983-05-31

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548195, 548196, C07D27742, C07D27744

Patent

active

043862101

ABSTRACT:
Novel syn isomers of 7-amino-thiazolyl-acetamido-3-acetoxymethyl-cephalosporanic acid derivatives of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of --CN, --CONH.sub.2 and --COOR.sub.1 ', R.sub.1 ' is selected from the group consisting of alkyl of 1 to 3 carbon atoms, hydrogen, alkali metal, alkaline earth metal, ammonium, magnesium and a non-toxic, pharmaceutically acceptable organic amine, A is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, ammonium, magnesium and a non-toxic, pharmaceutically acceptable organic amine, R' and R" are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms with the ##STR2## group in the syn position with the proviso that when R.sub.1 is --COOR.sub.1 ' and R.sub.1 ' is hydrogen, A is hydrogen and when R.sub.1 is --COOR.sub.1 ' and R.sub.1 ' is an alkali metal, alkaline earth metal, magnesium, ammonium or an organic amine, A is an alkali metal, alkaline earth metal, magnesium, ammonium or an organic amine having antibiotic properties and novel intermediates and processes.

REFERENCES:
patent: 4166115 (1979-08-01), Takaya et al.
patent: 4203899 (1980-05-01), Ochiai et al.
patent: 4288434 (1981-09-01), Heymes

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