2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating

Details 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating

1995-01-24

1996-06-11

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549403, A61K 3135, C07D31130

Patent

active

055256252

ABSTRACT:
2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran inhibits MEK and, as such, is effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.

REFERENCES:
patent: 3816466 (1974-06-01), Strandtmann et al.
patent: 5116954 (1992-05-01), Briet et al.
J. Med. Chem., 1991, 34, pp. 798-806, Cushman et al.
Anti-Cancer Drug Design, 1992, 7, pp. 365-384, Cunningham et al.
Acta Chemica Scandinavica, 1965, 19, pp. 823-832, Moses et al.

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