2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol

Details 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol

1997-03-04

1999-01-05

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

C07D47318, C07F 718

Patent

active

058564810

ABSTRACT:
The L-monovaline ester derived from 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.

REFERENCES:
patent: 4355032 (1982-10-01), Verheyden et al.
patent: 5043339 (1991-08-01), Beauchamp
E. Jensen et al., "Synthesis, enzymatic hydrolysis and physico-chemical properties . . . ", Acta Pharm. Nord., 3(4), 243-247 (1991).
J.C. Martin et al., "Synthesis and Antiviral Activity of Various Esters . . . ", J. Pharm. Sci., 76(2), 180-184 (1987).
P.C. Maudgal et al., "Topical Treatment of Experimental Herpes Simplex Keratouveitis . . . ", Arch. Ophthalmol., 102, 140-142 (1984).
L. Colla et al., "Synthesis and Antiviral Activity of Water-soluble Esters of Acyclovir . . . ", J. Med. Chem., 26, 602-604 (1983).
L.M. Beauchamp et al., "Amino acid ester prodrugs of acyclovir", Antiviral Chemistry & Chemotherapy, 3(3), 157-164 (1992).

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