2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanedi

Details 2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanedi 2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanedi

1997-03-04

2000-07-04

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544276, A61K 3152, C07D47318

Patent

active

060839538

ABSTRACT:
The L-monovaline ester derived from 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.

REFERENCES:
patent: 4355032 (1982-10-01), Verheyden et al.
patent: 5043339 (1991-08-01), Beauchamp
E. Jensen et al., "Synthesis, enzymatic hydrolysis and physico-chemical properties ... ", Acta Pharm. Nord., 3(4), 243-247 (1991).
J.C. Martin et al., "Synthesis and Antiviral Activity of Various Esters ... ", J. Pharm. Sci., 76(2), 180-184 (1987).
P.C. Maudgal et al., "Topical Treatment of Experimental Herpes Simplex Keratouveitis ... ", Arch. Ophthalmol., 102, 140-142 (1984).
L. Colla et al., "Synthesis and Antiviral Activity of Water-soluble Esters of Acyclovir ... ", J. Med. Chem., 26, 602-604 (1983).
L.M. Beauchamp et al., "Amino acid ester prodrugs of acyclovir", Antiviral Chemistry & Chemotherapy, 3(3), 157-164 (1992).

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