2-(2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carbo

Details 2-(2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carbo 2-(2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carbo

1983-09-28

1984-11-27

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424266, A61K 31455, C07D21182

Patent

active

044852398

ABSTRACT:
2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamide) glutaric acid of formula I and its disodium salt of formula II ##STR1## Said acid is obtained from glutaminic acid and dimethyl 3,5-diethoxycarbonyl-1,4-dihydroisonicotic acid.
For obtaining disodium salt, said acid is reacted with a caustic soda solution.
These compounds possess antiarrhythmic activity.

REFERENCES:
patent: 4351837 (1982-09-01), Materne
M. D. Mashkovsky, "Medicinal Preparations" (Manual Book on Pharmacotherapy or Physicians), Part I, 8th Edition, revised & supplemented, Moscow, Meditsina Publishers, 1977, pp. 370 to 373 (fragment) and Translation enclosed.

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