2-(2,3-dicarboxycyclopropyl) glycine and method for producing th

Details 2-(2,3-dicarboxycyclopropyl) glycine and method for producing th 2-(2,3-dicarboxycyclopropyl) glycine and method for producing th

1993-04-29

1994-08-02

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C22946

Patent

active

053347579

ABSTRACT:
(2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)-glycine (DCG-I) and (2S,1'S,2'S,3'S)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-II), as well as methods for synthesizing these compounds are provided. Studies on L-glutamate receptors with the use of DCG-I and DCG-II, which are agonists for NMDA receptors, contribute to the development of remedies for various nervous disorders. Further, DCG-I and DCG-II selectively inhibit monosynaptic reflex even at a low concentration, which makes them useful as a remedy for spastic palsy, an anesthetic and an analgesic.

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K. Shimamoto et al., "Synthesis of Four Diastereomeric L-2-(Carboxycyclopropl)glycines, Conformationally Constrained L-Glutamate Analogues", Reprinted from The Journal of Organic Chemistry, 1991, vol. 56.
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