2-(2,3,5,6-tetrafluoro-4-pyridyl)-1,2-benzisothiazol-3(2H)-one 1

Details 2-(2,3,5,6-tetrafluoro-4-pyridyl)-1,2-benzisothiazol-3(2H)-one 1 2-(2,3,5,6-tetrafluoro-4-pyridyl)-1,2-benzisothiazol-3(2H)-one 1

1994-02-07

1995-10-03

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546272, 544131, 544360, 5142368, 514254, C07D41704, A61K 3144

Patent

active

054552559

ABSTRACT:
2-(2,3,5,6-Tetrafluoro-4-pyridyl)-1,2-benzisothiazol-3(2H)one 1,1-dioxides of the formula I: ##STR1## pharmaceutical compositions containing them and methods for the treatment of degenerative diseases utilizing them.

REFERENCES:
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Cha, Biochem. Pharmacol., 1975, 24, 2177-2185.
El-Maghraby et al., Proc. Indian Natl. Acad. Sci. Acad., Part A, 1987, 53(3), 431-440.
Yogi, et al., Bull. Chem. Soc. Jpn. 1987, 60, 731-735.
Badawi et al., Oriental J. Chem. 1986, 2(1), 40-44.
Rabhofer et al., Israel Journal of Chemistry 1979, 18, 249-252.
Rabhofer et al., Tetrahedron Lett. 1979, 14, 1217-1218.
Abramovitch et al., J. Org. Chem. 1974, 39(13), 1795-1801.
Ashe et al., J. Biol. Chem,. 1981, 256(22), 11603-11606.

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