2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aro

Details 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aro 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aro

1991-03-25

1992-03-24

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 24, C07D31178, C07D33504

Patent

active

050990373

ABSTRACT:
The present invention is directed to a group of compounds which are 2,19-methylenoxy or 2,19-methylenethio bridged steroids, and related steroidal compounds. These compounds are useful as aromatase and 19-hydroxylase inhibitors.

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Kocovsky, J. Org. Chem., 53, 5816 (1988).
Armas et al., J. Chem. Soc. Perkin Trans. I, 1989, 405.
Njar et al., Heterocycles, 28, 1051 (1989).

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