2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aro

Details 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aro 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aro

1994-03-18

1996-02-13

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

424 941, 435184, A61K 3158

Patent

active

054911362

ABSTRACT:
The present invention is directed to a method of using a certain compounds which are 2,19-methyleneoxy or 2,19 methylenethio bridged steroids, and related steroidal compounds as inhibitors of the enzyme steroid aromarase, 19-hydroxylase and as treatment for various estrogen dependent/mediated disorders including hormonal dependent breast cancer.

REFERENCES:
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Counsell, R. E. et al. J. Med. Chem. 9(5):685-89 (1966).
Hendersen, D. Ann Med. 23:201-203 (1991).
Habenicht, U. F. et al., J. Steroid Biochem. Molec. Biol. 44(4-6):557-63 (1993).
El Etreby, M. F., J. Steroid Biochem. Molec. Biol. 44(4-6):565-72 (1993).
Schweikert, H. U. et al., J. Steroid Biochem. Molec. Biol. 44(4-6):573-76 (1993).
Burkhart, et al., J. Org. Chem., 57:5150-5154 (1992).
Johnston, et al. J. Steroid Biochem. Molec. Biol. vol. 44; No. 4-6 pp. 623-632 1993; Biological Characterization of A-Ring Steroids.
Schweikert, H. U. and Tunn, U. W., Steroids 50(1-3):191-200 (1987).

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