2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives

Details 2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives 2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives

1980-02-25

1984-09-04

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544358, 544368, 544369, 544370, 544373, 544376, 544392, 544399, A61K 31495, C07D24104

Patent

active

044696949

ABSTRACT:
2-(1-Piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives are disclosed. The derivatives exhibit dopamine-receptor stimulating activity in a mammal and are useful for treating hyperprolactinemia, galactorrhea, amenorrhea, impotence, Parkinsonism, diabetes, acromegaly, hypertension and other central nervous system disorders.

REFERENCES:
Sianesi, et al., "J. Med. Chem.", vol. 10, 1967, pp. 1144-1148.
Biggi, et al., "J. Amer. Chem. Soc.", vol. 94, 1972, pp. 4700-4707, vol. 95, 1973, pp. 7101-7107.
Toda, et al., "Chemical Abstracts", vol. 76, 1972, col. 72185f.
Veracini, et al., "J. Chem. Soc. Commun.", 1977, pp. 623-624.
Abadir, et al., "J. Chem. Soc.", 1952, pp. 2350-2353.
Nozoe, et al., "Chemical Abstracts", vol. 70, 1969, col. 87244z.

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