2-(1,2,4-oxadiazol-5-yl) and 2-(1,3,4-thiadiazol-2-yl-imidazo[1,

Details 2-(1,2,4-oxadiazol-5-yl) and 2-(1,3,4-thiadiazol-2-yl-imidazo[1, 2-(1,2,4-oxadiazol-5-yl) and 2-(1,3,4-thiadiazol-2-yl-imidazo[1,

1985-12-12

1987-10-27

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514267, 544281, 544250, A61K 31415, C07D23502

Patent

active

047030496

ABSTRACT:
Novel compounds selected from the group consisting of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of 1,2,4-oxadiazol-5-yl and 1,3,4-thiadiazol-2-yl, both optionally substituted with alkyl of 1 to 3 carbon atoms or alkenyl of 2 to 5 carbon atoms and 1,2,4-oxadiazol-3-yl and 1,3,4-oxadiazol-2-yl, both optionally substituted with alkenyl of 2 to 5 carbon atoms, alkyl of 1 to 3 carbon atoms or alkyl of 1 to 3 carbon atoms substituted with at least one fluorine, R.sub.2 and R.sub.3 are individually selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms and alkenyl of 2 to 5 carbon atoms or together form alkylene of 3 to 5 carbon atoms, X is selected from the group consisting of --O-- and --S--, R.sub.4 is alkyl of 1 to 3 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having anxiolytic sedative and hypnotic activity and a novel process and novel intermediates therefor.

REFERENCES:
patent: 4588720 (1986-05-01), Tully et al.

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