2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-carbapenem derivativ

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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540350, C07D48704, A61K 3140

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active

055345107

ABSTRACT:
Novel carbapenem compounds, (1R,5S,6S)-2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-6-[(R)-1-hydroxyeth yl]-1-methyl-carbapen-2-em-3 -carboxyic acid derivatives.
These carbapenem compounds are represented by the following formula having a beta-coordinated methyl group introduced at the 1-position and a [1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio group introduced at the 2-position. ##STR1## In the formula, R is hydrogen; lower alkyl group which is unsubstituted or substituted by hydroxy, lower alkoxy or lower alkoxy-lower alkoxy group; group --COOR.sup.1 (R.sup.1 is hydrogen or lower alkyl group); or group --CONR.sup.2 R.sup.3 (R.sup.2 and R.sup.3 are, independently each other, hydrogen or lower alkyl), and
Y is carboxy, --COO.sup..crclbar. or protected carboxy.
These compounds are useful antibiotics for prevention and treatment of bacterial infections.

REFERENCES:
patent: 5102997 (1992-04-01), Sugimura et al.
Patent Abstracts of Japan, vol. 13, No. 63, Feb. 13, 1989, & JP 63 255 280.

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