Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-07-16
1996-12-03
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544 10, A61K 3154, C07D51304
Patent
active
055808697
ABSTRACT:
1N substituted pyrazino[2,3-c]-1,2,6-thiadiazine 2,2-dioxides of formula I ##STR1## where: R.sub.1 and R.sub.2, which may be the same or different, are members of the group formed by hydrogen, straight or branched chain alkyl, aryl, trifluoromethyl, halogen, oxo, amino, carboxamido and alkoxycarbonyl;
REFERENCES:
Journal of Heterocyclic Chemistry, vol.27,No.3,1990, Provo,U.S., pp. 785-786 P. Goya et al. "Reactivity of 4-amino-6,7-diphenyl-8H-pyrazino(2-3-c)-1,2,6-thiadiazine 2,2-dioxide towards methylating agents".
Liebigs Annalen Der Chemie,No.3,1991, Weinheim,Germany, pp. 301-303 I. Alkorta et al. "Pyrazino(2-3-c)thiadiazine, 2,2-dioxides. Synthesis of SO.sub.2 analogues of folic acid antagonists".
Heterocycles, vol. 27, No.9, 1988, Amsterdam, Netherlands, pp. 2201-2211 P. Goya et al. "Tautomerism in pyrazino(2,3-c)-1,2,6-thiadiazine 2,2-dioxides".
Liebigs Annalen Der Chemie, No.2,1988, Weinheim, Germany, pp. 121-124 P.Goya et al. "Pteridine analogues; Synthesis and physico-chemical properties of 7-oxopyrazino(2,3-c)(1,2,6)thiadiazine 2,2-dioxides".
Chemical Abstracts, vol.106, No.1, 1987, Columbus, Ohio, U.S., Abstract No. 5092y, L.Goya et al. "Pyrazinothiadiazine S,S-dioxides", page 479.
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Goya et al., Chemical Abstracts, vol. 117, entry 212458q (1992).
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Carrasco Yufera Emilio
Grau Mateo Manuel
Laza Pilar G.
Paez Prosper Juan A.
Consejo Superior de Investigaciones Cientificas
Ford John M.
Prodesfarma, S.A.
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