1H-tetrazole-5-carboxamides

Details 1H-tetrazole-5-carboxamides 1H-tetrazole-5-carboxamides

1976-03-23

1977-08-23

Drezin, Norman A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

260308D, 424250, 424251, 424263, 424270, A61K 3141, C07D25704

Patent

active

040441440

ABSTRACT:
Anti-allergic agents of N-aromatic and N-heterocyclic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, .alpha.-naphthyl, .beta.-naphthyl, phenyl, 2,6-dichlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2, 3, 4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylsulfinyl, lower alkoxy, hydroxy(lower)alkoxy, 2-(lower alkoxy oxalyloxy)ethoxy, N-mono- and di-lower alkylamino(lower)-alkoxy, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, mono- and di- lower alkylamino, carboxy, lower alkylcarbonyl, cyano, carb(lower)alkoxy, phenoxy(lower)alkoxy, lower alkoxyoxalamido and lower alkoxyoxalamidophenoxy radicals;
And pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 3578674 (1971-05-01), Buckler
patent: 3824249 (1974-07-01), Regnier et al.
patent: 3887574 (1975-06-01), Ellis et al.
Fisher et al., J. Organic Chem., vol. 24, 1650-1654. (1959)

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