1H-pyrimido[4,5-b]indole derivatives, their preparation and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate



The invention concerns compounds of general formula (I):Wherein n, X, Y, R1and R2are as defined herein. The invention also concerns a method for preparing the compounds and their therapeutic use.

patent: WO 93/20078 (1993-10-01), None
patent: 96/26941 (1996-09-01), None
patent: WO 96/26941 (1996-09-01), None
Bundy, G. L., et. al., Synthesis of 2,4-Di-1-Pyrrolidinyl-9H-Pyrimido[4,5-b]Indoles, Including Antiasthma Clinical Candidate PNU-142731A, ORganic Process Research and Development, (2001), vol. 5, pp. 144-151.
Bundy, G. L., et. al., Synthesis of Novel 2,4-Diaminopyrrolo[2,3-d]Pyrimidines with Antioxidant, Neuroprotective, and Antiasthma Activity, J. Med. Chem. (1995) vol. 38, pp. 4161-4163.
Dotzauer, B., et. al., Synthesis of Medicinally Interesting 2, 4-Diamino-9H-Pyrimido[4,5-b]Indol-6-ols via Extension of the Nenitzescu Reaction, Synlett, (2004), vol. 6, pp. 1039-1043.
Kondo, Y., et. al., Condensed Heteroaromatic Ring Systems. XVI. Synthesis of Pyrrolo[2,3-d]Pyrimidine Derivatives, Database CA, Database accession No. 1990:459080, Chemical & Pharmaceutical Bulletin, vol. 37, No. 11, 2933-6 (1989).


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