1H-pyrazole-1-(branched)alkanamides as antiarrhythmic agents, co

Details 1H-pyrazole-1-(branched)alkanamides as antiarrhythmic agents, co 1H-pyrazole-1-(branched)alkanamides as antiarrhythmic agents, co

1989-12-28

1991-01-29

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514326, 540603, 546211, 548374, 548378, A61K 31415, C07D23112

Patent

active

049887254

ABSTRACT:
N-[(alkylamino)alkyl]-3,4(or 4,5)-diaryl-1H-pyrazole-1-(branched)alkanamides and pyrazole-1-alkanamines useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic acid with an appropriate diamine followed by reduction or by reacting the anion of a lower-alkyl ester of a pyrazole-1-acetic acid with an alkylating agent followed by displacement of the ester by an appropriate amine.

REFERENCES:
patent: 4072498 (1978-02-01), Moon et al.
patent: 4182895 (1980-01-01), Bailey
patent: 4695566 (1987-09-01), Heinemann et al.
patent: 4870095 (1989-09-01), Bailey

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