1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use

Details 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use

1989-03-22

1989-09-26

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514326, 514404, 540603, 546211, 548363, 548364, 548367, 548374, 548378, A61K 31415, C07D23112, C07D23120

Patent

active

048700959

ABSTRACT:
N-[(disubstituted amino)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate diamine or by reacting a lower-alkyl ester of a pyrazole-1-acetic or propanoic acid with an .omega.-aminoalkanol, followed by activation of the alcohol and displacement by an appropriate amine.

REFERENCES:
patent: 4072498 (1978-02-01), Moon et al.
patent: 4182895 (1980-01-01), Bailey
patent: 4695566 (1987-09-01), Heinemann et al.

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