1H-indole-3-acetic acid hydrazide sPLA.sub.2 inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548494, 548135, 548253, 548414, 514 92, 514381, 514362, C07D20918, C07D40306, A61K 31405, A61K 3141

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active

055786340

ABSTRACT:
A class of novel 1H-indole-3-acetic acid hydrazides is disclosed together with the use of such indole compounds for inhibiting sPLA.sub.2 mediated release of fatty acids (e.g., arachidonic acid) for treatment of conditions such as septic shock.

REFERENCES:
patent: 2825734 (1958-03-01), Speeter, M.
patent: 2890223 (1959-06-01), Woolley
patent: 3196162 (1965-07-01), Sarett
patent: 3242162 (1966-03-01), Sarett
patent: 3242163 (1966-03-01), Sarett
patent: 3242193 (1966-03-01), Sarett
patent: 3271416 (1966-09-01), Shen
Seilhamer, Jeffrey, et al., "Cloning and Recombinant Expression of Phospholipase A.sub.2 present in Rheumatoid Arthritic Synovial Fluid"; The Journal of Biolgical Chemistry, 254:10, Apr. 5, 1989, pp. 5335-5338.
Kramer, Ruth, et al., "Structure and Properties of a Human Non-Pancreatic Phospholipase A.sub.2 ", The Journal of Biological Chemistry, 264.10, Apr. 5, 1989, pp. 5768-5775.
Shaw, Elliott, "The Synthesis of Tryptamines Related to Serotonin", Journal American Chemical Soc., vol. 77, Aug. 20, 1955, pp. 4319-4324.
Julia, Marc, et al., "No. 193--Recherches en serie indolique". Memoire No. V: Bull. Soc. Chim., 1962, 1042.
Walton, Edward, et al., "Some Analogs of 1-p-Chlorobenzyl-5-methylindole-3-acetic Acid", J. Med. Chem., vol. 11, 1968, pp. 1252-1255.
Romeo, E., "2-Aryl-3-Indoleglyoxylamides (FGIN-1): A New Class of Potent and Specific Ligands for the Mitochondrial DBI Receptor (MDR)", The Journal of Pharmacology and Experimental Therapeutics, vol. 262, No. 3, pp. 971-978 (1992).
Carlin, Robert B., et al., "Studies on the Fischer Indole Synthesis I", Journal American Chemical Society, vol. 70, Oct. 1948, pp. 3421-3424.
Yoshihiko Ito, et al., "The First Total Synthesis of OPC-15161", J. Org. Chem., 1991, 56, pp. 4864-4867.
Clark, Robin D., et al., "Preparation of Indoles and Oxindoles from N-(Tert-Butoxycarbonyl)-2-Alkylanilines", Synthesis, Oct. 1991, pp. 871-878.
Wayland, E. Noland, et al., "Nitration of Indoles II, The Mononitration of Methylindoles", J. Org. Chem., vol. 28, Sep. 1963, pp. 2262-2266.
Miyaura, N., et al., "The Palladium-Catalyzed Cross-Coupling Reaction of Phenylboronic Acid with Haloarenes in the Presnce of Bases", Synthetic Communications, 11:7 1981, pp. 513-519.
Reynolds, et al., "Analysis of Human Synovial Fluid Phospholipase A.sub.2 on Short Chain Phosphatidylcholine-Mixed Micelles; Development of a Spectrophotometric Assay Suitable for a Microtiterplate Reader", Analytical Biochem, 204, 1992, pp. 190-197.
Rossum, et al., "Cumulative Dose-Response Curves", Arch. Int. Pharmacodyn, 143, No. 3-4, 1963, pp. 299-330.
Waud, Douglas R. "Analysis of Dose-Response Relationships", Advances in General and Cellular Pharmacology, eds., Narahashi, Branchi, 1:145-178, 1976.
Julia, Marc. et al., "No. 193--Recherches en serie indolique." Memoire No. VI: Bull. Soc. Chim., 1962, 1060.

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