1H-indazole-3-acetic acids as aldose reductase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514322, 5142345, 514866, A61K 31415

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active

052369455

ABSTRACT:
Abstract Certain 1H-indazole-3-acetic acid derivatives, and their pharmaceutically-acceptable esters and salts, are inhibitors of the aldose reductase enzyme, and so are useful in the treatment of diabetic complications.

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Pederson et al.--Abstract No. 321, 25th Meeting of the European Associates for the Study of Diabetes, Sep. 20-23, 1989.
Blohme and Smith--Abstract No. 47, 25th Annual Meeting of the European Associates for the Study of Diabetes, Sep. 20-23, 1989.
The Sorbinil Neuropathy Study Group--Abstract No. 55, Diabetes 38, May 1989.
Jaspan et al.--Abstract No. 56, Diabetes 38, May 1989.
Corsi et al., J. Med. Chem., vol. 19, pp. 778-783 (1976).
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Shibakawa et al., Current Chemotherapy and Infectious Disease, Proc. 11th ICC and 19th ICAAC, Am. Soc. of Microbiol., pp. 469-470, May 1980.

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