1H-indazole-3-acetic acids as aldose reductase inhibitors

Details 1H-indazole-3-acetic acids as aldose reductase inhibitors 1H-indazole-3-acetic acids as aldose reductase inhibitors

1993-02-24

1994-07-19

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514373, 514379, 514394, 514406, 5142338, 5142345, 5142352, 514321, 514322, 548159, 548207, 548217, 548241, 5483051, 5483611, 546199, 546198, 544135, 544137, 544139, 544140, A61K 3138, C07D41706

Patent

active

053309979

ABSTRACT:
Certain 1H-indazole-3-acetic acid derivatives, and their pharmaceutically-acceptable esters and salts, are inhibitors of the aldose reductase enzyme, and so are useful in the treatment of diabetic complications.

REFERENCES:
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 4130714 (1978-12-01), Sarges
Pederson, et al., Abstract No. 321, 25th Meeting of the European Associates for the Study of Diabetes, Sep. 20-23, 1989.
Blohme and Smith. Abstract No. 47, 25th Annual Meeting of the European Associates for the Study of Diabetes, Sep. 20-23, 1989.
The Sorbinil Neuropathy Study Group-Abstract No. 55, Diabetes 38, May, 1989.
Jaspan, et al., Abstract No. 56, Diabetes 38, May, 1989.
Corsi, et al. J. Med. Chem., vol. 19, pp. 778-783 (1976).
Wynganiden, et al., Textbook of Medicine, 16th Edition, pp. 1061-1065. Nov. 1983.
Shibakawa, et al., Current Chemotherapy and Infectious Disease, Proc. 11th ICC and 19th ICAAC, Am. Soc. of Microbiol., pp. 469-470 May (1980).

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