1H-imidazo[4,5-C]quinolin-4-amines as vaccine adjuvants

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

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4242781, 4242041, 4242311, 4242361, 424 931, 42419611, 546 26, 546 79, 546 81, 546 84, 548100, 548125, 548126, A61K 39385, A61K 4500

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060835052

ABSTRACT:
An immunogen/vaccine adjuvant composition containing an immunogen in an amount effective to stimulate an immune response and as a vaccine adjuvant a 1H-imidazo[4,5-c]quinolin-4-amine in an amount effective to increase the immune response to the immunogen.

REFERENCES:
patent: 4619827 (1986-10-01), Bull et al.
patent: 4689224 (1987-08-01), Bull et al.
patent: 4689338 (1987-08-01), Gerster
patent: 4716168 (1987-12-01), Alaimo et al.
patent: 4806352 (1989-02-01), Cantrell
patent: 4929624 (1990-05-01), Gerster et al.
patent: 5015476 (1991-05-01), Cochrum et al.
patent: 5026543 (1991-06-01), Rijke
patent: 5026546 (1991-06-01), Hilgers et al.
patent: 5037986 (1991-08-01), Gerster
patent: 5149529 (1992-09-01), Ho et al.
patent: 5268376 (1993-12-01), Gerster
patent: 5346905 (1994-09-01), Gerster
patent: 5389640 (1995-02-01), Gerster et al.
Warren et al "Current Status of Immunological Adjuvants", Ann. Rev. Immunol., 1986, 4, pp. 369-388.
J. Immunol., 1975, 115, 575-578 (Smith et al.).
Infection and Immunity , 1978, 22, 62-68 (Langford et al.).
J. Infectious Diseases, 1986, 153, (Poindexter et al.) 772-778.
Immunology, 1986, 58, 203 (Micusan et al.).
J. Clin. Invest., 1984, 73, 1312 (Ikejima et al.).
Chen, M., Griffith, B.P., Lucia, H.L. and Hsiung, G.D., "Efficacy of S-26308 Against Guinea Pig Cytomegalovirus Infection", Antimicrobial Agents and Chemotherapy, 32, (5), 678-683, 1988.
Harrison, C.J., Jenski, L., Voychehovski, T., and Bernstein, D.I., "Modification of Immunological Responses and Clinical Disease During Topical R-837 Treatment of Genital HSV-2 Infection", Antiviral Research (10), 209-224, 1988.
Kende, M., Lupton, H.W., and Canonico, P.G., "Treatment of Experimental Viral Infections with Immunomodulators", Advances in the Biosciences (68), 51-63, 1988.
S-26308. Drugs of the Future 14, (9), 870-871, 1989.
Bernstein, D.I., Harrison, C.J., "Effects of the Immunomodulating Agent R-837 on Acute and Latent Herpes Simplex Virus Type 2 Infections", Antimicrobial Agents and Chemotherapy 33, (9), 1511-1515, 1989.
S-26308. Drug of the Future (15), No. 9, 967-968, 1990.
Harrison, C.J., Stanberry, L.R., and Bernstein, D.I., "Effects of Cytokines and R-837, a Cytokine Inducer, on UV-Irradiation Augmented Recurrent Genital Herpes in Guinea Pigs", Antiviral Research (15), 315-322, 1991.
Edelman et al (1990) "Adjuvants" Intern. Rev. Immunol. 7:51-66.
Allison et al (1992) "Immunological Adjuvants and Their Mode of Action" in Vaccines: New Approaches to Immunological Problems ed by R. W. Ellis, Butterworth-Heinemann, MA pp. 431-449.
Mechanisms of Interferon Actions vol. II ed. L. M. Pfeffer CRC Press, Inc Boca Raton, Fl Chapter 12 "Interferon-Mediated Modulation of the Immune System" by H.M. Johnson pp. 59-77.
Playfair et al (1987) Clin. Exp. Immunol 67:5-10.
Grob et al (1984) Eur J. Clin. Microbiol 3(3):195-198.
Heath et al (1989) Immunology 67:520-524.

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