(1H-azol-1-ylmethyl)substituted quinoline derivatives

Details (1H-azol-1-ylmethyl)substituted quinoline derivatives (1H-azol-1-ylmethyl)substituted quinoline derivatives

1991-05-23

1993-02-09

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546157, 546156, 5483351, 5483137, 5483461, 5483441, 5483151, 5483154, C07D40106, A61K 3147

Patent

active

051853469

ABSTRACT:
(1H-azol-1-ylmethyl)substituted quinoline derivatives, compositions containing the same, and methods of treating mammals suffering from disorders which are characterized by an increase proliferation and/or abnormal differentation of epithelial tissues.

REFERENCES:
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patent: 4792561 (1988-12-01), Walker et al.
patent: 4859684 (1989-08-01), Raeymaekers et al.
Bell et al., J. Med. Chem., 1989, 32, 1552-1558-2(1H)-Quinolinones with Cardiac Stimulant Activity. 3. Synthesis and Biological Properties of 6-Imidazol-1-yl Derivatives.
leclerc et al., J. Med. Chem. 1986, 29, 2427-2432-Cardiotonic Agents. 1. Synthesis and Structure-Activity Relationships in a New Class of 3-, 4-, and 5-Pyridyl-2(1H)-quinolone Der's.
Alabaster et al., J. Med. Chem. 1988, 31, 2048-2056-2(1H)-Quinolinones with Cardiac Stimulant Activity. 1. Synthesis and Biological Activities of (Six-Membered Heteraryl)-Substituted Derivs.

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