Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-01-15
2008-01-15
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S262200
Reexamination Certificate
active
10662477
ABSTRACT:
The present invention relates to a group of 1H-1,2,4-triazole-3-carboxamide derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing at least one of these compounds as an active ingredient.These 1H-1,2,4-triazole-3-carboxamide derivatives are potent cannabinoid-CB1receptor agonists, partial agonists, inverse agonists or antagonists, useful for the treatment of disorders involving cannabinoid neurotransmission.The compounds have the general formula (I)wherein R and R1-R3have the meanings given in the specification.
REFERENCES:
patent: 4795484 (1989-01-01), Aoki et al.
patent: 5624941 (1997-04-01), Barth et al.
patent: WO 01 29007 (2001-04-01), None
patent: WO 01/29007 (2001-04-01), None
patent: WO 01 58869 (2001-08-01), None
patent: WO 01/58869 (2001-08-01), None
Jagerovic, N. et al., “A Novel Class of Heterocyclic Cannabinoids: Design, Preparation, In Vitro and In Vivo Studies of 1,2,4-Triazoles”, Drugs Fut 2002, vol. 27 (Suppl. A): XVIIthInt. Symp. on Medical Chemistry, pp. 271, (2002).
Harhash, A. H. et al., “Reactions of 2-Aryl-4-arylhdrazonon-Δ2-oxazonlin-5-ones with Acid Amides & Diamines”, Indian Journal of Chemistry, vol. 14B, pp. 268-272, (Apr. 1976).
Elnagdi, M. H. et al., “Studies with Polyfunctionally Substituted Heteroaromatics: 2-Phenyl-4-p-Tolylhydrazono-2-oxazoline-5-one as a Precursor for the Synthesis of Substituted 1,2,4-Triazoles and Pyridines”, Heteroatom Chemistry, vol. 6, No. 6, pp. 589-592, (1995).
Clerin, D. et al., “No. 42.—Hétérocyclisation des α-acylaminoamides. III—Propriétés des amino-5 oxazoles”, Bull. Soc. Chim. Fr., No. 1-2, Pt.2, pp. 211-217, (1974).
Dyck, et al., “Potent Imidazole and Triazole CB1Receptor Antagonists Related to SR141716,”Bioorganic&Medicinal Chemistry Letters, 14:1151-1154 (2004).
Harhash et al., “Reactions of 2-aryl-4-arylhydrazono-.DELTA. 2-oxazolin-5-ones with acid amides and diamines,” XP002225874 Abstract,6001 Chemical Abstracts, 85(23) (1976).
Elnagdi et al., “Studies with Polyfunctionally Substituted Heteroaromatics: 2-phenyl-4-p-tolylhydrazono-2-oxazoline-5-one as a Precursor for the Synthesis of Substituted 1,2,4-Triazoles and Pyridines,” XP-002225875 Abstract,6001 Chemical Abstracts, 124(17), (1996).
Jagerovic et al., “A Novel Class of Heterocyclic Cannabinoids: Design, Preparation, in vitro and in vivo Studies of 1,2,4-Triazoles,” XP-001121041 Abstract,Drugs Future 27(Suppl. A):XVIthInt. Symp. on Medicinal Chemistry(2002).
Kruse Cornelis G.
Lange Josephus H. M.
McCreary Andrew C.
Stuivenberg Herman H. van
Anderson Rebecca
Chung Susannah
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Solvay Pharmaceuticals B.V.
LandOfFree
1H-1,2,4-triazole-3-carboxamide derivatives having... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1H-1,2,4-triazole-3-carboxamide derivatives having..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1H-1,2,4-triazole-3-carboxamide derivatives having... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3950046