1H-1,2,3-triazol-5-ylthio ester of N-carbobenzyloxy-p-hydroxyphe

Details 1H-1,2,3-triazol-5-ylthio ester of N-carbobenzyloxy-p-hydroxyphe 1H-1,2,3-triazol-5-ylthio ester of N-carbobenzyloxy-p-hydroxyphe

1981-09-02

1984-07-31

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 26, 548136, 548151, C07D24918

Patent

active

044631790

ABSTRACT:
Novel thioesters effective as acylating agents for amines or hydrazines, especially effective as active esters in synthesis of cephalosporin compounds are disclosed. The novel thioester of the present invention can be prepared by reacting a thiol or a derivative thereof with an acetic acid derivative or a reactive derivative thereof. By reacting the thioester of the present invention with a 7-aminocephalosporin derivative or a salt thereof, cephalosporin derivatives or pharmacologically acceptable salts thereof which are excellent antibiotic substances having a high antimicrobial activity can be obtained in high yield very safely.

REFERENCES:
patent: 3946003 (1976-03-01), Cooper
patent: 4144391 (1979-03-01), Hatfield
patent: 4258195 (1981-03-01), Shibuya et al.
patent: 4351947 (1982-09-01), Shibuya et al.

Affiliated with

Also associated with

Rating

1H-1,2,3-triazol-5-ylthio ester of N-carbobenzyloxy-p-hydroxyphe does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1H-1,2,3-triazol-5-ylthio ester of N-carbobenzyloxy-p-hydroxyphe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1H-1,2,3-triazol-5-ylthio ester of N-carbobenzyloxy-p-hydroxyphe will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-186656