19-substituted progesterone derivatives useful as 19-hydroxylase

Details 19-substituted progesterone derivatives useful as 19-hydroxylase 19-substituted progesterone derivatives useful as 19-hydroxylase

1988-06-28

1990-03-20

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514178, 514179, 514181, 514182, 2603973, 2603974, 26039745, 26039745, 2603975, A61K 3156, C07J 100

Patent

active

049101919

ABSTRACT:
19-Substituted progesterone derivatives and related compounds which are active as 19-hydroxylase inhibitors and useful as antihypertensive agents are described herein. The compounds are prepared using appropriate synthetic pathways which will vary according to the nature of the specific 19-substituted progesterone or related compound desired.

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patent: 3275622 (1966-09-01), Bowers
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patent: 4753932 (1988-06-01), Teutsch
CA 65:12268a (1966).
Pietro de Ruggieri et al., Tetrahedron Letters, 23, 2195-2200 (1967).

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