19-nor-vitamin D.sub.3 compounds with calcemic activity

Details 19-nor-vitamin D.sub.3 compounds with calcemic activity 19-nor-vitamin D.sub.3 compounds with calcemic activity

1999-05-13

1999-11-09

Clardy, S. Mark

Organic compounds -- part of the class 532-570 series

Organic compounds

9,10-seco-cyclopentanohydrophenanthrene ring system or...

514167, C07C40100, A61K 3159

Patent

active

059817801

ABSTRACT:
The 26 and/or 27 homologated analogs of 19-nor-1.alpha.,25-dihydroxyvitamin D.sub.3 are disclosed as having relatively high calcemic activity. The 26 and/or 27 homologated analogs showed strong in vivo calcium transport as well as bone calcium mobilization activity. These analogs also induced differentiation of malignant cells. These analogs thus show promise in the treatment of osteoporosis, and a possible use in the treatment of cancerous diseases.

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Perlman et al, "Novel Synthesis of 19-Nor-Vitamin D Compounds," Tetrahedron Letters, vol. 52, No. 52, pp. 7663-7666, 1991.
Perlman et al, "1.alpha.,25-Dihydroxy-19-Nor-Vitamin D.sub.3, A Novel Vitamin D-Related Compound with Potential Therapeutic Activity," Tetrahedron Letters, vol. 31, No. 13, pp. 1823-1824, 1990.

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