19-nor-vitamin D.sub.3 compounds with calcemic activity

Details 19-nor-vitamin D.sub.3 compounds with calcemic activity 19-nor-vitamin D.sub.3 compounds with calcemic activity

1998-08-18

1999-10-05

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

9,10-seco-cyclopentanohydrophenanthrene ring system or...

514167, C07C40100, A61K 3159

Patent

active

059627077

ABSTRACT:
The 26 and/or 27 homologated analogs of 19-nor-1.alpha.,25-dihydroxyvitamin D.sub.3 are disclosed as having relatively high calcemic activity. The 26 and/or 27 homologated analogs showed strong in vivo calcium transport as well as bone calcium mobilization activity. These analogs also induced differentiation of malignant cells. These analogs thus show promise in the treatment of osteoporosis, and a possible use in the treatment of cancerous diseases.

REFERENCES:
patent: 4847012 (1989-07-01), DeLuca et al.
patent: 4851401 (1989-07-01), DeLuca et al.
patent: 5086191 (1992-02-01), DeLuca et al.
patent: 5281731 (1994-01-01), DeLuca et al.
patent: 5393749 (1995-02-01), DeLuca et al.
patent: 5587497 (1996-12-01), DeLuca et al.
Perlman et al, "Novel Synthesis of 19-Nor-Vitmain D Compounds," Tetrahedron Letters, vol. 32, No. 52, pp. 7663-7666, 1991.
Perlman et al, "1.alpha.,25-Dihydroxy-19-Nor-Vitamin D.sub.3, A Novel Vitamin D-Related Compound with Potential Therapeutic Activity," Tetrahedron Letters, vol. 31, No. 13, pp. 1823-1824, 1990.

Affiliated with

Also associated with

Rating

19-nor-vitamin D.sub.3 compounds with calcemic activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 19-nor-vitamin D.sub.3 compounds with calcemic activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 19-nor-vitamin D.sub.3 compounds with calcemic activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1173340