Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1990-02-16
1993-08-17
Shaver, Paul F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
568664, 560179, 560182, 560194, 560198, 556437, 556445, 556449, C07C 4304, C07C 4318
Patent
active
052371107
ABSTRACT:
This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.
REFERENCES:
patent: 4410515 (1983-10-01), Holick et al.
DeLuca Hector F.
Perlman Kato L.
Prahl Jean M.
Schnoes Heinrich K.
Sicinski Rafal R.
Shaver Paul F.
Wisconsin Alumni Research Foundation
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