Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1996-04-25
1999-03-09
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
552653, A01N 4500, C07C40100
Patent
active
058801138
ABSTRACT:
This invention provides a novel class of vitamin D-related compounds, namely the 1c-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.
REFERENCES:
patent: 5587497 (1996-12-01), DeLuca et al.
DeLuca Hector F.
Perlman Kato L.
Prahl Jean Martin
Schnoes Heinrich K.
Sicinski Rafal R.
Dees Jos,e G.
Pryor Alton N.
Wisconsin Alumni Research Foundation
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