Organic compounds -- part of the class 532-570 series – Organic compounds – 9,10-seco-cyclopentanohydrophenanthrene ring system or...
Patent
1995-11-17
1998-01-20
Prior, Kimberly J.
Organic compounds -- part of the class 532-570 series
Organic compounds
9,10-seco-cyclopentanohydrophenanthrene ring system or...
C07C40100
Patent
active
057102945
ABSTRACT:
This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.
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DeLuca Hector F.
Perlman Kato L.
Prahl Jean Martin
Schnoes Heinrich K.
Sicinski Rafal R.
Prior Kimberly J.
Wisconsin Alumni Research Foundation
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