19-nor-pregnane steroids as neurochemical initiators of change i

Details 19-nor-pregnane steroids as neurochemical initiators of change i 19-nor-pregnane steroids as neurochemical initiators of change i

1995-06-07

1998-08-11

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514178, 514181, 514182, 552558, A61K 3156

Patent

active

057927570

ABSTRACT:
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor pregnane steroid, or a pharmaceutical composition containing a vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Other embodiments of the invention include pharmaceutical compositions containing the steroids.

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Berliner et al., "Estrene Steroids as Neurochemical Initiators of Change in Human Hypothalamic Function and Related Pharmaceutical Compositions and Methods", Abstract No. 122:152290, WO 9428903, 22 Dec. 1994, pp. 1-94.
Berliner et al., "Androstane Steroids as Neurochemical Initiators of Change in Human Hypothalamic Function and Related Pharmaceutical Compositions and Methods", Abstract No. 122:152289, WO 9428904, 22 Dec. 1994, pp. 1-89.
Jin et al., "Stereospecific Synthesis of Trifluoromethylated 1,3,5-trienes", Abstract No. 121:107573, Journal of Fluorine Chemistry, 1994, 67:1-4.
Schweder et al., "DELTA. 16-20-keto Steroids by C-2 Elongation from DELTA.16-17 Substituted Steroids", Abstract No. 120:31014, Journal Praktikal Chemistry, 1993, 335(5), pp. 439-444.
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