19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as

Details 19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as

1988-06-28

1990-04-24

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514178, 514179, 514182, 514181, 552539, 552526, 552515, 552561, 552588, 552587, 552583, 552600, 552601, 552602, C07J 100, A61K 3156

Patent

active

049201140

ABSTRACT:
19-Fluoro- and cyano- substituted 21-hydroxyprogesterone derivatives and related compounds which are active as 19-hydroxylase inhibitors and useful as antihypertensive agents are described herein. The compounds are prepared using appropriate synthetic pathways which will vary according to the nature of the specific 19-substituted progesterone or related compound desired.

REFERENCES:
patent: 3124574 (1964-03-01), Bowers
patent: 3154569 (1964-10-01), Ercoli et al.
patent: 3159620 (1964-12-01), Ercoli et al.
patent: 3186988 (1965-06-01), Bowers
patent: 3214427 (1965-10-01), Ercoli et al.
patent: 3257389 (1966-06-01), Bowers
patent: 3257435 (1966-06-01), Bowers et al.
patent: 3394128 (1968-07-01), Edwards

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