Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
1998-09-08
2002-07-16
Brusca, John S. (Department: 1631)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S006120, C536S023100
Reexamination Certificate
active
06420526
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to newly identified polynucleotides and the polypeptides encoded by these polynucleotides, uses of such polynucleotides and polypeptides, and their production.
Filing Date:
Applications:
1.
07-Mar-1997
60/040,162
2.
07-Mar-1997
60/040,333
3.
07-Mar-1997
60/038,621
4.
07-Mar-1997
60/040,626
5.
07-Mar-1997
60/040,334
6.
07-Mar-1997
60/040,336
7.
07-Mar-1997
60/040,163
8.
23-May-1997
60/047,600
9.
23-May-1997
60/047,615
10.
23-May-1997
60/047,597
11.
23-May-1997
60/047,502
12.
23-May-1997
60/047,633
13.
23-May-1997
60/047,583
14.
23-May-1997
60/047,617
15.
23-May-1997
60/047,618
16.
23-May-1997
60/047,503
17.
23-May-1997
60/047,592
18
23-May-1997
60/047,581
19.
23-May-1997
60/047,584
20.
23-May-1997
60/047,500
21.
23-May-1997
60/047,587
22.
23-May-1997
60/047,492
23.
23-May-1997
60/047,598
24.
23-May-1997
60/047,613
25.
23-May-1997
60/047,582
26.
23-May-1997
60/047,596
27.
23-May-1997
60/047,612
28.
23-May-1997
60/047,632
29.
23-May-1997
60/047,601
30.
11-Apr-1997
60/043,580
31.
11-Apr-1997
60/043,568
32.
11-Apr-1997
60/043,314
33.
11-Apr-1997
60/043,569
34.
11-Apr-1997
60/043,311
35.
11-Apr-1997
60/043,671
36.
11-Apr-1997
60/043,674
37.
11-Apr-1997
60/043,669
38.
11-Apr-1997
60/043,312
39.
11-Apr-1997
60/043,313
40.
11-Apr-1997
60/043,672
41.
11-Apr-1997
60/043,315
42.
06-Jun-1997
60/048,974
43.
22-Aug-1997
60/056,886
44.
22-Aug-1997
60/056,877
45.
22-Aug-1997
60/056,889
46.
22-Aug-1997
60/056,893
47.
22-Aug-1997
60/056,630
48.
22-Aug-1997
60/056,878
49.
22-Aug-1997
60/056,662
50.
22-Aug-1997
60/056,872
51.
22-Aug-1997
60/056,882
52.
22-Aug-1997
60/056,637
53.
22-Aug-1997
60/056,903
54.
22-Aug-1997
60/056,888
55.
22-Aug-1997
60/056,879
56.
22-Aug-1997
60/056,880
57.
22-Aug-1997
60/056,894
58.
22-Aug-1997
60/056,911
59.
22-Aug-1997
60/056,636
60.
22-Aug-1997
60/056,874
61.
22-Aug-1997
60/056,910
62.
22-Aug-1997
60/056,864
63.
22-Aug-1997
60/056,631
64.
22-Aug-1997
60/056,845
65.
22-Aug-1997
60/056,892
66.
22-Aug-1997
60/056,761
67.
23-May-1997
60/047,595
68.
23-May-1997
60/047,599
69.
23-May-1997
60/047,588
70.
23-May-1997
60/047,585
71.
23-May-1997
60/047,586
72.
23-May-1997
60/047,590
73.
23-May-1997
60/047,594
74.
23-May-1997
60/047,589
75.
23-May-1997
60/047,593
76.
23-May-1997
60/047,614
77.
11-Apr-1997
60/043,578
78.
11-Apr-1997
60/043,576
79.
23-May-1997
60/047,501
80.
11-Apr-1997
60/043,670
81
22-Aug-1997
60/056,632
82
22-Aug-1997
60/056,664
83
22-Aug-1997
60/056,876
84
22-Aug-1997
60/056,881
85
22-Aug-1997
60/056,909
86
22-Aug-1997
60/056,875
87
22-Aug-1997
60/056,862
88
22-Aug-1997
60/056,887
89
22-Aug-1997
60/056,908
90.
06-Jun-1997
60/048,964
91.
05-Sep-1997
60/057,650
92
22-Aug-1997
60/056,884
93
05-Sep-1997
60/057,669
94
13-Jun-1997
60/049,610
95
02-Oct-1997
60/061,060
96
08-Jul-1997
60/051,926
97
16-Jul-1997
60/052,874
98
12-Sep-1997
60/058,785
99
18 Aug-1997
60/055,724
100
07-Mar-1997
60/040,161
BACKGROUND OF THE INVENTION
Unlike bacterium, which exist as a single compartment surrounded by a membrane, human cells and other eucaryotes are subdivided by membranes into many functionally distinct compartments. Each membrane-bounded compartment, or organelle, contains different proteins essential for the function of the organelle. The cell uses “sorting signals,” which are amino acid motifs located within the protein, to target proteins to particular cellular organelles.
One type of sorting signal, called a signal sequence, a signal peptide, or a leader sequence, directs a class of proteins to an organelle called the endoplasmic reticulum (ER). The ER separates the membrane-bounded proteins from all other types of proteins. Once localized to the ER, both groups of proteins can be further directed to another organelle called the Golgi apparatus. Here, the Golgi distributes the proteins to vesicles, including secretory vesicles, the cell membrane, lysosomes, and the other organelles.
Proteins targeted to the ER by a signal sequence can be released into the extracellular space as a secreted protein. For example, vesicles containing secreted proteins can fuse with the cell membrane and release their contents into the extracellular space—a process called exocytosis. Exocytosis can occur constitutively or after receipt of a triggering signal. In the latter case, the proteins are stored in secretory vesicles (or secretory granules) until exocytosis is triggered. Similarly, proteins residing on the cell membrane can also be secreted into the extracellular space by proteolytic cleavage of a “linker” holding the protein to the membrane.
Despite the great progress made in recent years, only a small number of genes encoding human secreted proteins have been identified. These secreted proteins include the commercially valuable human insulin, interferon, Factor VIII, human growth hormone, tissue plasminogen activator, and erythropoeitin. Thus, in light of the pervasive role of secreted proteins in human physiology, a need exists for identifying and characterizing novel human secreted proteins and the genes that encode them. This knowledge will allow one to detect, to treat, and to prevent medical disorders by using secreted proteins or the genes that encode them.
SUMMARY OF THE INVENTION
The present invention relates to novel polynucleotides and the encoded polypeptides. Moreover, the present invention relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides. Also provided are diagnostic methods for detecting disorders related to the polypeptides, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying binding partners of the polypeptides.
DETAILED DESCRIPTION
Definitions
The following definitions are provided to facilitate understanding of certain terms used throughout this specification.
In the present invention, “isolated” refers to material removed from its original environment (e.g. the natural environment if it is naturally occurring), and thus is altered “by the hand of man” from its natural state. For example, an isolated polynucleotide could be part of a vector or a composition of matter, or could be contained within a cell, and still be “isolated” because that vector, composition of matter, or particular cell is not the original environment of the polynucleotide.
In the present invention, a “secreted” protein refers to those proteins capable of being directed to the ER, secretory vesicles, or the extracellular space as a result of a signal sequence, as well as those proteins released into the extracellular space without necessarily containing a signal sequence. If the secreted protein is released into the extracellular space, the secreted protein can undergo extracellular processing to produce a “mature” protein. Release into the extracellular space can occur by many mechanisms, including exocytosis and proteolytic cleavage.
As used herein, a “polynucleotide” refers to a molecule having a nucleic acid sequence contained in SEQ ID NO:X or the cDNA contained within the clone deposited with the ATCC. For example, the polynucleotide can contain the nucleotide sequence of the full length cDNA sequence, including the 5′ and 3′ untranslated sequences, the coding region, with or without the signal sequence, the secreted protein coding region, as well as fragments, epitopes, domains, and variants of the nucleic acid sequence. Moreover, as used herein, a “polypeptide” refers to a molecule having the translated amino acid sequence generated from the polynucleotide as broadly defined.
In the present invention, the full length sequence identified as SEQ ID NO:X was often generated by overlapping sequences contained in multiple clones (contig analysis). A representative clone containing all or most of the sequence for SEQ ID NO:X was deposited with the American Type Culture Collection (“ATCC”). As shown in Table 1, each clone is identified by a cDNA Clone ID (Identifier) and the ATCC Deposit Number. The ATCC is located at 10801 University Boulevard, Manassas, Va. 20110-2209, USA. The ATCC deposit was mad
Bednarik Daniel R.
Brewer Laurie A.
Carter Kenneth C.
Duan Roxanne
Ebner Reinhard
Brusca John S.
Human Genome Sciences Inc.
Human Genome Sciences, Inc
Kim Young
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