18-Phenyloestrane derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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540 41, 2603974, 2603973, 2603975, 514177, 514178, C07J 3300, C07J 100

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048087106

ABSTRACT:
A novel class of steroids having pregnancy-terminating and/or pregnancy-preventing activity and a very low antiglucocorticoid activity have been found. The compounds have the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each separately represent H or a (1-4 C) hydrocarbon radical or together represent a (2-6 C) hydrocarbon radical, R.sub.3 represents H or a (1-4 C) hydrocarbon radical, optionally having an OH substituent, R.sub.4 represents OH or an ester or ether group, or together with R.sub.3 represents O or a heterocyclic ring system containing O, and wherein the broken line indicates an optionally present double bond between the carbon atoms at positions 9 and 10 of the steroid skeleton.

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Keana J. F. W., "Protection of Carbonyl & Hydroxyl Groups" in Steroid Reactions, (1963), Holden-Day, Inc., (U.S.A.), pp. 1-5, 30, 34, 35.
Chemical Abstracts, vol. 66, No. 5, Jan. 30, 1967, p. 1828, Item 18810m.
Chemical Abstracts, vol. 66, Oct. 31, 1967, Item 18820q.

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