18-nor-vitamin D compounds

Details 18-nor-vitamin D compounds 18-nor-vitamin D compounds

1995-05-03

1997-08-26

Jordan, Charles T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

A61K 3159

Patent

active

056611404

ABSTRACT:
18-nor-vitamin D.sub.3 analogs in which the angular methyl group attached to carbon 13 of the CD-ring has been removed and replaced by a hydrogen atom. The 18-nor vitamin D compounds are characterized by relatively high cell differentiation activity, while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. These compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis, because of their preferential calcemic activity, and for the treatment of psoriasis due to their cell differentiation activity.

REFERENCES:
patent: 4851401 (1989-07-01), DeLuca et al.
patent: 5401731 (1995-03-01), Calverley et al.
patent: 5401732 (1995-03-01), Calverley et al.
patent: 5447924 (1995-09-01), Bretting
patent: 5449668 (1995-09-01), Sestelo et al.
Maynard et al, "18-Substituted Derivatives of Vitamin D: 18-Acetoxy-1,25-Dihydroxyvitamin D.sub.3 and Related Analogues", J. Org. Chem., vol. 57, 1992, pp. 3214-3217.
Nilsson et al, "Synthesis and Biological Evaluation of 18-Substituted Analogs of 1,25-Dihydroxyvitamin D.sub.3 ", Bioorg. Med. Chem. Letters, vol. 3, No. 9, 1993, pp. 1855-1858.
Biorganic & Medicinal Chemistry Letters, vol. 3, No. 9, pp. 1855-1858, 1993, "Synthesis and Biological Evaluation of 18-Substituted Analogs of 1.alpha., 25-Dihydroxyvitamin D.sub.3 ", Nilsson et al.
J. Org Chem., vol. 57, No. 11, pp. 3214-3217, 1992, "18-Substituted Derivatives of Vitamin D: 18-Acetoxy-1.alpha.,25-Dihydroxyvitamin D.sub.3 and Related Analogues", Maynard et al.

Affiliated with

Also associated with

Rating

18-nor-vitamin D compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 18-nor-vitamin D compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 18-nor-vitamin D compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1988636