170kD membrane-bound protease useful in diagnosis of malignant c

Details 170kD membrane-bound protease useful in diagnosis of malignant c 170kD membrane-bound protease useful in diagnosis of malignant c

1990-10-11

1993-06-22

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435219, 530828, C12N 964, C12N 950

Patent

active

052216225

ABSTRACT:
A novel 170 kD membrane protease is isolated from malignant human melanoma cell line LOX and RPMI7951. The protease is useful in a method of diagnosing cellular transformation.

REFERENCES:
patent: 4816400 (1989-03-01), Tryggvason et al.
Chen et al, J. of Cell Biology, vol. 98, Apr. 1984, pp. 1546-1555.
Baici et al, Invasion Metastasis, 4:13-27 (1984).
Chen et al, Proc. Natl Acad. Sci, Nov. 1990, 87(21) pp. 8296-8300.

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