170-Labeled phosphoric acid compound and method and apparatus fo

Details 170-Labeled phosphoric acid compound and method and apparatus fo 170-Labeled phosphoric acid compound and method and apparatus fo

1995-08-10

1998-01-13

Soderquist, Arlen

Chemistry: analytical and immunological testing

Nuclear magnetic resonance, electron spin resonance or other...

436 56, 436103, 436105, 1286532, 324300, 324307, 324309, 324322, G01N 2408, G01N 3300, G01V 300

Patent

active

057078750

ABSTRACT:
Using a mixed sample of a plurality of phosphoric acid compounds different in chemical structure as a sample for measurement, a .sup.31 P nuclear magnetic resonance signal obtained through polarization transfer between .sup.17 O and .sup.31 P is observed and signals obtained without polarization transfer are eliminated, whereby .sup.31 P nuclear magnetic resonance signal spectrum of an .sup.17 O-labeled phosphoric acid is selectively observed. For this purpose, a double resonance NMR detector capable of exciting .sup.17 O and .sup.31 P at the same time is connected to an NMR spectrometer, and using a pulse train which permits observation of a .sup.31 P nuclear magnetic resonance signal obtained through polarization transfer between .sup.17 O and .sup.31 P, a .sup.31 P nuclear magnetic resonance signal from the .sup.17 O-labeled phosphoric acid is observed, and signals for .sup.17 O-unlabeled .sup.31 P are eliminated.

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