17-heterocyclyl-14beta-5alpha-androstane, androstene and androst

Details 17-heterocyclyl-14beta-5alpha-androstane, androstene and androst 17-heterocyclyl-14beta-5alpha-androstane, androstene and androst

1993-09-29

1996-09-17

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540 96, 540 97, 540109, C07J 5100, A61K 3158

Patent

active

055568467

ABSTRACT:
17-Heterocyclyl-5.alpha.-14.beta.-androstane, androstene and androstadiene of formula (I): ##STR1## wherein: Y is oxygen or guanidinoimino, when a double bond exists at position 3;
Y is hydroxy, OR.sup.2 or SR.sup.2, when a single bond exists at position 3;
R is a saturated or unsaturated mono- or biheterocyclic ring, containing one or more heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen, unsubstituted or substituted by one or more of halogen, hydroxymethyl, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, sulfonamido, C.sub.1 -C.sub.6 lower alkyl or COR.sup.3 ; and
R.sup.1 is hydrogen, methyl, ethyl or n-propyl substituted by OH or NR.sup.4 R.sup.5.

REFERENCES:
patent: 3405127 (1968-10-01), Shaw
patent: 5244886 (1993-09-01), Scholz et al.

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