17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes

Details 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes

1978-04-05

1980-04-15

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424243, 26023955D, 2603971, 2602395, C07J 700, A61K 3158

Patent

active

041984030

ABSTRACT:
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 4-position with a fluoro, chloro or bromo and optionally substituted at the six position with fluoro or chloro are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9 alpha position with fluoro, chloro or bromo; substituted at the 11 with a keto, a beta-hydroxy or a beta-chloro (the latter only when there is a 9 alpha-chloro); substituted at 16 alpha,-17 alpha-positions with isopropylidenedioxy; and substituted at 16 alpha (or 16 beta) with methyl or hydrogen when there is a 17 alpha-hydroxy (or an ester).

REFERENCES:
patent: 3989686 (1976-11-01), Phillipps et al.
patent: 4093721 (1978-06-01), Phillipps et al.

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