17.beta.-thiocarboxylic acid esters of 3-oxo-4-halo-16.beta.-met

Details 17.beta.-thiocarboxylic acid esters of 3-oxo-4-halo-16.beta.-met 17.beta.-thiocarboxylic acid esters of 3-oxo-4-halo-16.beta.-met

1979-08-29

1981-04-14

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603971, 26039745, 26023955C, 26023955R, 26023955D, C07J 100, C07J 300, A61K 3156

Patent

active

042619840

ABSTRACT:
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17.beta.-thiocarboxylic acid esters substituted at the 4-position with a fluoro or chloro, optionally substituted at the 6- position with fluoro or chloro and at 16.beta. with methyl are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9.alpha. position with fluoro, chloro or bromo; substituted at the 11 with a keto, a beta-hydroxy or a beta-chloro (the latter only when there is a 9.alpha.-chloro); when there is a 17.alpha.-hydroxy (or an ester).

REFERENCES:
patent: 2897199 (1959-07-01), Ringold et al.
patent: 3489748 (1970-01-01), Els et al.
patent: 3707537 (1972-12-01), Kierstead
patent: 4188385 (1980-02-01), Edwards

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