17.beta.-SUBSTITUTED-ALLENE-BEARING STEROIDS

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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2602395, 2603974, 26039745, 2603975, 424243, C07D47100

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active

039780481

ABSTRACT:
Steroidal compounds of the invention bear a 17.beta.-oxygenated group and a 17.alpha.-.PSI.-alkyl substituted allene group, e.g., 17.alpha.-(penta-1'-2'-dienyl)-estra-4,9-dien-17.beta.-ol-3-one, and are prepared by a procedure, e.g., involving reacting a corresponding intermediate bearing a 17.alpha.-(3'-dialkylamino-3'-alkyl-substituted-1'-propynyl)-group with a complex hydride. The steroidal compounds are useful as pharmaceuticals, e.g., as progestational agents.

REFERENCES:
patent: 3888849 (1975-06-01), Bacso

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